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ChromaDex’s Niagen shows positive results in Alzheimer’s

ChromaDex’s Niagen shows positive results in Alzheimer’s 

ChromaDex's Niagen shows positive results in Alzheimer, Stockwinners.com
ChromaDex’s Niagen shows positive results in Alzheimer’s patients

ChromaDex (CDXC) announced results from its collaborative research agreement with the NIA and NIH which appear in the Feb. 5 issue of Proceedings of the National Academy of Sciences showing that Niagen nicotinamide riboside prevented neurological damage and improved cognitive and physical function in a new mouse model of Alzheimer’s disease that more closely resembles human AD than other mouse models.

These findings arrive a few months after results demonstrating that AD mice treated with NR had lower levels of amyloid deposits, improved mitochondrial energy production and improved memory in his paper, in the journal Nature.

Researchers found that the mice receiving Niagen had reduced tangles in their brains, higher neuroplasticity, less DNA damage, increased production of new neurons from neuronal stem cells, and lower levels of neuronal damage and death.

In fact, in the area of the brain which typically becomes damaged in individuals with dementia, Niagen appeared to either clear existing DNA damage or prevent it from spreading.

The study suggests that NR enters the brain and boosts cellular NAD+ levels when administered orally. The research team attributes the observed physical and cognitive benefits to the rejuvenating effect NR had on stem cells in both muscle and brain tissue.

CDXC closed at $4.82.

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Glaukos posts positive glaucoma data

iStent reduced IOP, lowered medication burden in patients

iStent reduced IOP, lowered medication burden in patients. Stockwinners.com
iStent reduced IOP, lowered medication burden in patients

Glaukos Corporation (GKOS) announced that a study published in the January 2018 issue of the Journal of Glaucoma showed that a single iStent Trabecular Micro-Bypass Stent implanted during cataract surgery in patients with severe open-angle glaucoma achieved mean postoperative intraocular pressure of 14.1 mm Hg and a 28% reduction in the mean number of glaucoma medications used after 36 months of follow-up.

The retrospective case series included 59 glaucomatous eyes with cataracts and severe visual field loss.

At baseline, the medicated mean IOP was 19.3 mm Hg and the mean number of topical glaucoma medications used per eye was 2.3. In 49 eyes followed for 24 months after iStent implantation and concomitant cataract surgery, mean postoperative IOP decreased to 14.9 mm Hg while the mean number of glaucoma medications used per eye declined to 1.6. In a consistent cohort of 32 eyes with available data through three years postoperative, the IOP reduction was maintained.

At three years, this cohort achieved a mean postoperative IOP of 14.1 mm Hg, from a baseline mean medicated IOP of 18.1 mm Hg, and a 28% reduction in mean glaucoma medications used per eye from 2.44 preoperatively to 1.75.

“While many prior studies have documented the clinical benefits of combining iStent implantation with cataract surgery in glaucoma patients who are in the mild to moderate stage of the disease, we believe this is the first published study to focus on its use in severe glaucoma patients undergoing cataract surgery,” said John Berdahl MD, a South Dakota-based ophthalmic surgeon and one of the article’s authors.

“Our study showed that severe glaucoma patients experienced sustained reductions in IOP and medication use through three years postoperative.”

GKOS closed at $29.26.

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